What Is Particle Size Analysis ?

18-02-2025

Particle size is the measurement of the dimensions of individual particles that make up a material. Particle size can range from nanometers to millimeters. The most common way to measure particle size is using a particle size analyser.

Particle size is a critical factor in product quality across various industries. Implementing a robust particle analysis method within your quality control processes is essential. But what exactly does particle size analysis entail?

In this article, we will define what particle size analysis is, why it's important, and how particles are recorded.

What Is Particle Size Analysis ?

Particle size is the measurement of the dimensions of individual particles that make up a material. Particle size can range from nanometers to millimeters. The most common way to measure particle size is using a particle size analyser.

Why is particle size important ?

  • Particle size is important in many applications, including manufacturing, ecology, and biology.
  • It affects the physical and chemical properties of a material, such as its strength, reactivity, and load-bearing properties.
  • It's used to control the quality of many industrial products, such as cosmetics, pharmaceuticals, and printer toner.

How to determine Particle Size of a sample?

Dynamic Light Scattering method {DLS} is most commonly used to analyse the particle size as per Brownian motion of particles observed and Measurement range is 0.6 nm* – 10 μm.

The particle size can affect the rate a substance will dissolve. Smaller particles have a smaller surface area, therefore making dissolution occur more quickly. The pharmaceutical industry uses this information when designing drugs, as drugs with a smaller surface area will be metabolized more quickly.Particle size plays an important role for bioavailability of formulations.

How Otsuka's particle size analyser helps in determining the particle sizes?

Otsuka Elzneo works on the principle of Dynamic light scattering & measures particle size, zeta potential and molecular weight of a particle. It can be used for particle concentration measurement, microrheology and structural analysis of gel networks.

It works on the principal of Dynamic light scattering which measures fluctuations in scattered light intensity due to Brownian motion of particles.

Key features :

  • Capable of measuring from dilute to highly concentrated suspensions.
  • Measuring Range : 0.6nm to 10nm
  • Concentration Range: 0.00001 to 40%
  • Measurement time is average 1 min.
  • It can see the size difference of the particles have similar sizes with higher separability achieved by 3 angles measured.
  • Multi-angle Measurement(46°,90°,165°)
  • The measurement is performed from three angles, forward, side and back. It can provide information of number of particles by carrying out particle concentration measurement.
  • It can measure particle size distribution of particles which have similar sizes with higher separability achieved by multi-angle measurement and to obtain information of number of particles.
  • It has applications to analyze nanoparticles in Pharma, with DDS in Liposomes.
  • Examples include determining Nanomaterial size, protein size, latex size, and colloid size.
  • In general, the technique is best used for submicron particles and can be used to measure particle with sizes less than a nanometer.
  • Particle size evaluation of various proteins and Particle size evaluation of colloidal gold as application.

What concerns do you have when measuring particle size ?

  • R & D
  • Multiple conditions
  • Production
  • Multiple Samples at a time
  • Quality Management
  • Production
  • It is also recommended for use in quality management
  • One time setup
  • Fast! 1 Sample / Min : Takes 1 minute to measure one sample
  • Easy to understand user interface
  • Possible to add samples during measurement
  • Convenient

Applications of Otsuka Particle Size Analyser

  • Particle Size and its diameter helps in evaluation of proteins of different molecular weights
  • Determining Severe test evaluation of eye drops by particle diameter measurement
  • Heat transfer analysis of bovine serum albumin by dynamic light scattering
  • Heat denaturing analysis of Lysozyme by dynamic light scattering Of particles of DDS nano-material liposome
  • Dynamic light scattering measurements of gel formation process
  • Food Industry for determining the particle size of milk, coffee and sports and probiotic drinks.

Particle size analysis is an important parameter in Material Science. Labindia Instruments offers other advanced techniques to perform the analysis. To know more about our solutions, write us at enquiry@labindia.com

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