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Brand: Sepragen
Category: Chromatography Consumables & Accessories
Industry: Life Science and Biotechnology, Pharma, Bio-pharma & Vaccine, Clinical Research & Diagnostics
The QuantaSep® 10000 is a high-flow, mobile, and sanitary chromatography system engineered for large-scale bioprocessing and GMP manufacturing.
Delivering a dynamic flow range of 100 mL/min to 10 L/min, this powerful system can process 3000+ liters of cell culture batch in a single shift — setting a new benchmark for productivity, scalability, and compliance in industrial purification workflows.
Built with disposable tubing, dual precision pumps, and advanced buffer management, the QuantaSep® 10000 enables fully automated, reproducible, and traceable chromatography for production-scale environments.
Designed for GMP-grade purification and process scalability, the QuantaSep® 10000 integrates the entire chromatography workflow — from buffer switching and gradient formation to fraction collection and process monitoring — into a compact, mobile platform.
Its dual positive displacement pumps deliver consistent, pulsation-free flow across the full operating range, while the integrated inline mixer, filters, and fraction valves ensure efficient separation and purity at every stage.
The intuitive software suite allows users to automate critical process steps based on pH, conductivity, pressure, volume, or time, with real-time feedback from integrated sensors.
Comprehensive event and alarm logging, including air detection, leaks, and overpressure conditions, ensures full GMP compliance and data integrity for regulated production environments.
With on-line buffer dilution capabilities and bioprocess-grade disposable flow paths, the QuantaSep® 10000 combines industrial robustness with modern sanitary design — delivering high-throughput purification with precision and control.
High-Throughput Process Chromatography Automation
Complete automation of gradient formation, buffer switching, and collection for seamless operation.
Disposable Sanitary Flow Path
Ensures sterility, minimizes cleaning validation, and accelerates batch changeovers.
Integrated Sensor Suite
Monitors pH, conductivity, and pressure continuously for optimal control and reproducibility.
Intelligent Process Logic Control
Automatically executes method steps based on user-defined sensor thresholds or process conditions.
Comprehensive Digital Data Management
Full logging of methods, alarms, and events for GMP compliance and audit readiness.
Precision Buffer Dilution System
Performs accurate on-line dilution from concentrated buffers to enhance efficiency and reduce storage requirements.
Wide Flow Range: 100 mL/min to 10 L/min — ideal for full-scale GMP purification
Dual Positive Displacement Pumps: Delivers precise, pulsation-free flow control
Disposable Sanitary Tubing: Ensures contamination-free operation and rapid turnaround
Advanced Buffer Management: 8 buffer selection valves with integrated inline mixer
On-Line Buffer Dilution: Enables dilution from concentrates, reducing storage needs
Multi-Sensor Integration: Real-time pH and conductivity monitoring (pre- and post-column)
Automated Fraction Collection: 6 programmable fraction valves for continuous operation
Bidirectional Flow Control: Forward and reverse operation for versatile purification strategies
Comprehensive Alarm System: Alerts for air, leaks, overpressure, and sensor deviations
Data Logging and Archival: Automatic event and condition recording for compliance and traceability
Compact, Mobile Configuration: Built for portability and ease of use within GMP facilities
Purify at Scale. Perform with Precision.
The QuantaSep® 10000 brings industrial-grade automation to GMP chromatography — combining high flow performance, disposable sanitary design, and real-time process intelligence.
With its 100 mL–10 L/min flow range, on-line dilution, and fully automated control, it enables biopharmaceutical manufacturers to purify thousands of liters per shift — reliably, reproducibly, and in full compliance with GMP standards.
| Parameter | Specification |
|---|---|
| Flow Rate Range | 100 mL/min – 10 L/min |
| Pump Type | Dual positive displacement pumps |
| Tubing Type | Sanitary, single-use disposable flow path |
| Buffer Management | 8 buffer selection valves with inline mixer |
| Fraction Collection | 6 programmable fraction valves |
| Sensor Integration | pH and conductivity (pre- and post-column) |
| Flow Direction | Forward and reverse flow |
| Buffer Dilution | On-line dilution from concentrated buffers |
| Process Control | Time, volume, pressure, pH, and conductivity feedback |
| Software Platform | Intuitive, Windows®-based control interface |
| Event Logging | Full audit trail for alarms, process data, and methods |
| System Design | Compact, mobile, GMP-compliant configuration |
Monoclonal Antibody Production
Optimized for large-batch purification of therapeutic antibodies and biosimilars.
Vaccine and Viral Vector Processing
Delivers stable, high-volume purification for vaccine intermediates and viral platforms.
Protein and Enzyme Manufacturing
Industrial-scale purification with precise flow control and reproducible performance.
GMP Manufacturing and Validation
Fully compliant design for regulated, large-scale biopharmaceutical environments.
Continuous and Batch Chromatography
Flexible operation modes for continuous processing or batch purification.
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