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Brand: Sepragen
Category: Chromatography Consumables & Accessories
Industry: Life Science and Biotechnology, Pharma, Bio-pharma & Vaccine
The QuantaSep® 15000 IBD System is a dual-function, high-capacity chromatography and buffer dilution platform designed for large-scale bioprocessing and GMP manufacturing.
Operating at flow rates up to 15 L/min, it enables both chromatography and independent precision buffer dilution — combining two critical unit operations into a single, intelligent, and flexible system.
By utilizing 2X–10X concentrated buffers, the QuantaSep® 15000 IBD significantly reduces buffer preparation time, storage requirements, and facility footprint — all while maintaining tight process control and reproducibility.
The QuantaSep® 15000 IBD (Integrated Buffer Dilution) system redefines process efficiency by integrating chromatographic purification and automated buffer dilution into one seamless platform.
This innovative dual-function design allows operators to run chromatographic columns at up to 15 L/min, using highly concentrated buffers (2X–10X) that are precisely diluted on demand.
The system combines dual high-precision positive displacement pumps, automated buffer management, and advanced in-line mixing control to deliver unparalleled performance and accuracy.
Engineered for GMP production environments, the QuantaSep® 15000 IBD minimizes manual intervention and maximizes productivity with comprehensive software automation, sensor feedback, and real-time process control.
Its powerful control software enables independent or synchronized operation of chromatography and buffer dilution, while maintaining full data integrity, event logging, and compliance traceability.
The result: faster workflows, reduced buffer volume requirements, and uncompromising purity — all in a compact, mobile, and sanitary configuration.
Integrated Chromatography and Buffer Dilution
Seamlessly combines two critical downstream functions to reduce process complexity and increase throughput.
Precision Inline Buffer Dilution
Achieves exact dilution ratios from concentrated buffer stocks, improving facility efficiency and reducing preparation time.
Automated Process Logic
Executes step changes, buffer switching, and dilution adjustments based on sensor feedback and programmed logic.
High-Performance Pumping System
Dual positive displacement pumps provide consistent, pulsation-free flow across all operating ranges.
Advanced Digital Control and Data Logging
Comprehensive recording of process data, alarms, and events for GMP compliance and validation readiness.
High Flow Range: Up to 15 L/min for large-scale purification
Integrated Dual Functionality: Performs chromatography and independent precision buffer dilution within a single system
On-Demand Buffer Dilution: Enables the use of 2X–10X concentrated buffers to save space and time
Dual Positive Displacement Pumps: Provides accurate, pulsation-free flow control
Advanced Inline Mixing: Delivers consistent and homogeneous dilution across a wide concentration range
Full Automation and Control: Programmable operations based on volume, pressure, pH, conductivity, or time
Real-Time Monitoring: Continuous sensing of key parameters ensures process stability
GMP-Ready Design: Supports compliance with full event logging, alarms, and batch records
Compact, Mobile Configuration: Designed for flexibility and ease of integration in production suites
| Parameter | Specification |
|---|---|
| Flow Rate Range | Up to 15 L/min |
| System Type | Integrated Chromatography and Buffer Dilution (IBD) |
| Pump Type | Dual positive displacement pumps |
| Buffer Concentration | Handles 2X–10X concentrated buffers |
| Inline Mixing Control | Automated precision dilution and mixing |
| Sensor Integration | pH, conductivity, pressure, and flow monitoring |
| Process Control Modes | Time, volume, pressure, pH, and conductivity feedback |
| Software Platform | Advanced Windows®-based control interface |
| Event Logging | Complete data and alarm archival for GMP documentation |
| System Design | Compact, mobile, sanitary configuration for large-scale use |
Monoclonal Antibody Purification
High-throughput purification of mAbs and biosimilars with precise buffer control.
Vaccine and Viral Vector Production
Efficient large-batch purification with integrated buffer preparation for continuous workflows.
Protein and Enzyme Manufacturing
Optimized process performance with on-demand buffer generation and controlled chromatography.
GMP Bioprocessing
Fully automated, compliant system for large-scale production environments.
Continuous and Batch Chromatography
Supports both continuous processing and traditional batch purification workflows.
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