Name: Pilot Scale Columns
Brand: Sepragen
SKU: AJM4LLD3
Availability: InStock

Pilot Scale Columns

AJM4LLD3

Brand: Sepragen

Category: Chromatography Consumables & Accessories

Industry: Life Science and Biotechnology, Pharma, Bio-pharma & Vaccine, Clinical Research & Diagnostics

The Superflo® Pilot-Scale Columns are engineered for process development, pilot-scale separations, and small-scale production runs, delivering performance and scalability between laboratory and process environments.

Available in 5L to 10L volumes with an effective bed depth of 5.0 cm, these columns combine robust engineering, uniform flow dynamics, and material versatility to provide a reliable platform for method validation and scale-up studies.

Constructed from biocompatible acrylic or solvent-resistant stainless steel, Superflo® Pilot Columns are available with optional sanitary fittings, ensuring compatibility with regulated and GMP-ready environments.

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The Superflo® Pilot-Scale Series serves as the critical link between lab-scale development and full-scale GMP production, offering a platform that mirrors process-scale performance while maintaining the flexibility required for R&D and pilot studies.

Each column is designed with optimized radial flow geometry and a 5.0 cm effective bed depth, ensuring superior flow uniformity, low pressure drop, and high mass transfer efficiency — essential for reliable process characterization and method transfer.

The acrylic version offers clear visibility for process observation and validation, while the stainless-steel variant features sanitary end fittings for aseptic operation and long-term durability.
With easy media packing, modular assembly, and compatibility with standard bioprocess systems, Superflo® Pilot Columns deliver reproducible, high-quality separations that can be seamlessly scaled up to process-scale Superflo® columns.

Core Technologies

Radial Flow Design
Enables even flow distribution, reducing channeling and improving mass transfer efficiency.
Sanitary Construction (SS Models)
Stainless-steel variants are supplied with sanitary fittings and accessories, ensuring compliance with GMP and hygienic standards.
Consistent Scale-Up Geometry
Maintains proportional bed depth and flow path for accurate process development and reproducibility.
Dual Material Options
Offers flexibility between visual monitoring (acrylic) and industrial-grade robustness (stainless steel).

Volume Range: 5L to 10L
Effective Bed Depth: 5.0 cm for consistent flow and separation efficiency
Material Options:
- Acrylic: Transparent and biocompatible for visual inspection during process runs
- Stainless Steel: Solvent-compatible and supplied with sanitary end fittings
Sanitary Design: Stainless-steel units supplied with sanitary accessory sets for cleanroom compatibility
Uniform Flow Distribution: Ensures reproducible chromatography performance
Easy Assembly and Packing: Simple setup for resin packing and unpacking
Scalable Architecture: Ideal for process development and transfer to production-scale systems

From Development to Production — Scale Seamlessly.
The Superflo® Pilot-Scale Columns (5L–10L) provide a precise, scalable, and hygienic solution for pilot-scale chromatography and process optimization.
With 5.0 cm bed depth, sanitary construction, and consistent radial flow performance, these columns bridge the critical gap between lab research and GMP production — ensuring confidence, compliance, and reproducibility at every stage of scale-up.

Parameter	Specification
Column Volume Range	5L – 10L
Effective Bed Depth	5.0 cm
Material Options	Acrylic or Stainless Steel
Flow Geometry	Radial Flow
Sanitary Fittings	Included with stainless-steel models
Chromatography Modes	Ion Exchange, Affinity, Hydrophobic Interaction
Operating Environment	Pilot-scale and process development
Scalability	Directly scalable to Superflo® Process Columns (10L–200L)

Pilot-Scale Chromatography
Bridge the gap between research and GMP manufacturing with process-representative separations.
Protein, Peptide, and Enzyme Purification
Ideal for mid-scale purification, process validation, and optimization studies.
Vaccine and Viral Vector Processing
Supports pilot-scale viral and vaccine purification prior to full-scale production.
Process Development and Method Transfer
Optimize chromatography parameters for direct scalability to Superflo® Process-Scale Columns.
Small-Scale GMP Manufacturing
Designed for controlled, repeatable performance in regulated environments.

Pilot Scale Columns