Name: WEDGE Radial Columns
Brand: Sepragen
SKU: IYBKQDSS
Availability: InStock

WEDGE Radial Columns

IYBKQDSS

Brand: Sepragen

Category: Chromatography Consumables & Accessories

Industry: Life Science and Biotechnology, Pharma, Bio-pharma & Vaccine, Clinical Research & Diagnostics

The WEDGE® Radial Columns are engineered to maximize separation efficiency and productivity while minimizing operating pressure.

Integrating the advantages of Radial Flow and traditional Axial Flow chromatography designs, the WEDGE® system enables simple, linear scale-up from laboratory columns to large-scale production systems without compromising resolution or reproducibility.

Available in 5L to 10L sizes with a 5.0 cm effective bed depth, these columns are designed to fully exploit the capacity of soft or high-flow media, ensuring high yield, low pressure, and superior process control across a wide range of bioprocess applications.

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The WEDGE® Radial Column Series represents a major advancement in bioprocess chromatography design, combining the best attributes of axial flow and radial flow technologies.
This innovative design ensures efficient mass transfer, even flow distribution, and consistent chromatographic performance — even when working with low-cost soft media or high-flow-rate resins.

With a 5.0 cm bed depth and optimized geometry, WEDGE® Radial Columns provide exceptional uniformity and scalability, making them ideal for process validation, pilot production, and intermediate-scale manufacturing.
The result is high productivity, better sample distribution, and greater yield consistency — all with reduced pressure and operational complexity.

Core Technologies

Hybrid Radial–Axial Flow Design
Combines the uniform flow distribution of radial geometry with the simplicity of axial flow systems for scalable, reproducible performance.
Optimized Flow Dynamics
Ensures consistent pressure profiles and enhanced mass transfer efficiency across all chromatography modes.
Linear Scale-Up Architecture
Guarantees direct process transfer from lab-scale development to production-scale purification.
High Productivity Operation
Designed for higher yields, better sample distribution, and lower cycle times.

Volume Range: 5L to 10L
Effective Bed Depth: 5.0 cm
Flow Geometry: Integrated Radial and Axial Flow design
Media Compatibility: Suitable for soft gels and high-flow resins
Linear Scale-Up: Directly scalable from lab to production columns
High Flow Rates: Operates efficiently at elevated flow velocities
Low Pressure Operation: Reduces shear and stress on soft media
High Productivity: Maximizes process throughput and efficiency
Easy Validation: Simplified, repeatable packing and cleaning procedures
Consistent Performance: Uniform distribution ensures reproducible results

Redefining Scale-Up — The Power of Radial and Axial Flow Combined.
The WEDGE® Radial Columns (5L–10L) deliver exceptional scalability, efficiency, and reproducibility for modern bioprocessing.
By uniting radial flow performance with axial flow simplicity, these columns achieve higher throughput, lower pressure, and superior yield — making them the trusted choice for pilot-scale and process development in chromatography-driven production environments.

Parameter	Specification
Column Volume Range	5L – 10L
Effective Bed Depth	5.0 cm
Flow Geometry	Combined Radial and Axial Flow Design
Media Compatibility	Soft gels and high-flow-rate resins
Pressure Profile	Low operating pressure
Flow Rate	High flow capacity for enhanced productivity
Scale-Up Capability	Linear and reproducible
Operating Use	Pilot to process-scale chromatography

Pilot-Scale Chromatography
Bridge development and production with high-throughput separations.
Protein and Peptide Purification
Achieve high resolution with minimal backpressure.
Enzyme, Vaccine, and Biomolecule Isolation
Ideal for mid- to large-scale bioprocessing workflows.
Process Development and Optimization
Scale up validated methods with consistent chromatographic geometry.
Soft Media and High-Flow Resin Processing
Compatible with a wide range of chromatography materials and conditions.

WEDGE Radial Columns