For more than 25 years, WPI has pioneered biosensor technology, offering sensors that combine unmatched selectivity, low detection limits, and broad dynamic response.
Each biosensor is engineered to detect specific chemical species — from gaseous mediators such as nitric oxide and carbon monoxide to biochemical markers like glucose and hydrogen peroxide — with nM-level sensitivity.
WPI’s biosensors are among the only commercially available electrodes of their kind globally, enabling researchers to perform quantitative, real-time measurements in complex biological systems.
Used extensively in academic, clinical, and industrial settings, WPI’s biosensors are referenced in thousands of peer-reviewed publications and remain the standard for electrochemical biosensing accuracy and reliability.
Available Sensor Types
| Sensor Type |
Model Example |
Compatible Analyzers |
Primary Application |
| Carbon Monoxide (CO) |
ISO-COP-2 |
TBR4100 / TBR1025 |
Real-time CO detection in vivo or in vitro |
| Glucose |
ISO-Glu Series |
TBR4100 / TBR1025 / Apollo |
Long-term in vivo glucose monitoring |
| Hydrogen Peroxide (H₂O₂) |
ISO-HPO-2 / ISO-HPO-100 |
TBR4100 / TBR1025 |
Quantitative peroxide detection in biological systems |
| Hydrogen Sulfide (H₂S) |
ISO-H₂S-2 |
TBR4100 / TBR1025 |
Micromolar-level H₂S measurement in vitro |
| Nitric Oxide (NO) |
ISO-NOP Series |
TBR4100 / TBR1025 |
Real-time NO detection with sub-nM sensitivity |
Sensor-Specific Highlights
Carbon Monoxide (CO) Sensors — ISO-COP-2
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Enables real-time in vivo/in vitro CO detection.
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Ideal for studying endogenous CO signaling.
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Works seamlessly with TBR4100 and TBR1025 analyzers.
Glucose Sensors
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Implantable and long-term monitoring capability for chronic studies.
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Patented technology ensures stable glucose detection in vivo or in vitro.
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Fully compatible with Apollo, TBR4100, and TBR1025 systems.
Hydrogen Peroxide (H₂O₂) Sensors
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Provides quantitative, low nM detection of hydrogen peroxide in biological systems.
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Available in multiple designs:
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Features replaceable membrane sleeves and refillable electrolytes.
Hydrogen Sulfide (H₂S) Sensors
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Detects micromolar H₂S concentrations in blood and tissues.
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The only commercially available H₂S sensor for biological research.
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Enables study of vascular and signaling roles of hydrogen sulfide.
Nitric Oxide (NO) Sensors
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The world’s most comprehensive range of NO sensors.
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Features unique anti-interference membrane for enhanced selectivity.
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Capable of sub-nanomolar detection (0.2–1 nM).
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Ideal for studies in cells, tissues, microvessels, and single-cell systems.
Representative NO Sensor Models
| Model |
Diameter |
Response Time |
Detection Limit |
Sensitivity |
Drift |
Physiological Interference |
| ISO-NOPF |
100–500 µm |
<5 sec |
0.2 nM |
10 pA/nM |
None |
None |
| ISO-NOP |
2 mm |
<5 sec |
1 nM |
2 pA/nM |
None |
None |
| ISO-NOP30L / NOP30 |
30 µm |
<3 sec |
1 nM |
1.4 pA/nM |
None |
None |
| ISO-NOP007 |
7 µm |
<3 sec |
0.5 nM |
1 pA/nM |
None |
None |
| ISO-NOPNM |
100 nm |
<3 sec |
0.5 nM |
0.5 pA/nM |
None |
None |
Sensor Performance Factors
| Parameter |
Definition |
Importance |
| Response |
Change in current per unit concentration (nA/µM or pA/nM) |
Indicates sensitivity — higher response = higher signal output. |
| Detection Limit |
Minimum detectable concentration change above noise |
Lower limits signify greater precision and sensor quality. |
| Drift |
Baseline variation over time |
Stability indicator for long-term measurements. |
| Selectivity |
Sensor’s ability to ignore other ions/species |
Ensures accuracy in complex biological media. |
| Linearity |
Proportional relationship between signal and concentration |
Simplifies calibration and quantitative analysis. |
All WPI electrochemical biosensors maintain a linearity coefficient (R²) ≥ 0.9, ensuring consistent and reliable calibration across concentration ranges.
