Since their introduction in the mid-1980s, WPI’s TEER measurement systems have become the international standard for evaluating the growth, health, and confluence of epithelial tissue cultures in vitro.
A sharp rise in TEER values indicates cellular monolayer confluence — allowing researchers to monitor tissue integrity and barrier function in real time, without damaging the culture.
Building upon decades of innovation, WPI continues to expand its TEER and Ussing product lines, offering manual and automated instruments that integrate seamlessly with WPI amplifiers, electrodes, and data acquisition systems.
For epithelial physiology and transport studies, WPI’s Ussing Systems provide a fast, low-resistance electrical interface with modern design improvements such as short Ag/AgCl half-cells that eliminate the need for long agar bridges — ensuring ease of use, signal stability, and reproducible data.
TEER Measurement Systems
Reliable Quantification of Epithelial Barrier Integrity
WPI’s TEER (Trans Epithelial Electrical Resistance) instruments provide real-time, quantitative data on epithelial and endothelial cell monolayers.
They are designed for cell culture applications including drug discovery, diffusion studies, and barrier permeability testing, where precise monitoring of monolayer integrity is essential.
Key Features:
-
Non-destructive measurement of cell monolayers
-
High sensitivity and rapid response
-
Ideal for epithelial and endothelial tissue cultures
-
Compatible with WPI chambers, electrodes, and data systems
-
Manual and automated TEER measurement models available
Applications:
Epithelial permeability, drug diffusion, cell monolayer integrity testing, and toxicological assessments.
Ussing Systems
Precision Tools for Ion Transport and Electrophysiological Analysis
WPI’s Ussing Systems enable researchers to study ion, nutrient, and drug transport across barrier tissues such as epithelial or mucosal layers.
Each system consists of a tissue-holding chamber, perfusion setup, and precision electrode assemblies, providing low-noise, low-resistance measurements optimized for electrophysiological performance.
Highlights:
-
Simplified design for quick, stable electrical connections
-
Ag/AgCl half-cells that screw into short tubes for easy chamber integration
-
Eliminates need for Calomel half-cells and long agar bridges
-
Integrates with WPI amplifiers and data acquisition units
-
Ideal for electrophysiology and epithelial transport research
Applications:
Ion transport, nutrient absorption, epithelial electrophysiology, and barrier tissue permeability studies.
